solimis.blogg.se - Two tank approach pervaporation

#Two tank approach pervaporation drivers#
#Two tank approach pervaporation series#

In addition, the difluorinated byproduct 7 was typically observed at the ∼5% level. The reaction gave a mixture of diastereomers of 5 and 6 the undesired trans isomer 5 was the major product in a ∼2:1 ratio to the desired cis isomer 6. In the early generation of the synthesis, 2 was prepared from electrophilic fluorination of its precursor 4a via enolation followed by reaction with N-fluorobenzenesulfonimide ( Scheme 2). The complexity of the active pharmaceutical ingredient (API) synthesis arises primarily from chiral lactam 2 featuring three contiguous stereocenters. (1) Compound 1 (2) ( Scheme 1) is a potent and selective IRAK4 inhibitor currently under clinical development. IRAK4 is an attractive therapeutic target for diseases associated with dysregulated inflammation, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis.

#Two tank approach pervaporation drivers#

Inhibition of IRAK-4 blocks the production of inflammatory cytokines such as type-I interferons, IL-6, tumor necrosis factor (TNF), IL-1, and IL-12 that are key drivers of autoimmune and inflammatory diseases. Interleukin-1 receptor associated kinase 4 (IRAK4) is a serine threonine kinase that serves as a key node in innate immune signaling and is activated by the interleukin 1 (IL-1) family receptors (IL-1R, IL-18R, and IL-33R) as well as the Toll-like receptors (TLRs). An integrated flow oxidation of a γ-butyrolactam substrate provides an efficient and diastereoselective synthesis of a key lactam intermediate for the preparation of a drug candidate targeting interleukin-1 receptor associated kinase 4 for the treatment of inflammation and oncology diseases.

min –1 for more than 96 h, achieving the target of 0.15 wt % water.

The pervaporation skid has been successfully implemented in production by continuously generating anhydrous 1.5 M TBHP solution in nonane at a rate of up to 100 mL

#Two tank approach pervaporation series#

The system consists of membrane modules in series that are made of perfluorinated polymer with very high gas permeability, allowing it to remove water efficiently. Herein we describe a membrane pervaporation method that allows the production of the anhydrous TBHP solution in continuous manner. Despite the versatility in organic reactions, the use of anhydrous TBHP has been greatly limited because of safety concerns over its shipping, handling, and storage, particularly on production scale. Anhydrous tert-butyl hydroperoxide (TBHP) is a powerful oxidizing agent in many chemical transformations.